Cells must sense extracellular signals and transfer the information contained about their environment reliably to make appropriate decisions. ~ English biologist Margaritis Voliotis et al
Cell sickness is characterized by a cell dropping social communication; leaving various feedback loops unanswered. Cancer cells arise this way: following their own inner voice while ignoring orders to cease and desist. Then, as a cellular sociopath, cancer turns intercellular communication to its own ends.
Cancer starts in one tissue before it spreads to certain types of secondary tissue. The mystery of metastasis lies in communication. Cancer cells decide secondary infection by trying to start a conversation with new tissues. Those that answer are invaded. By this, breast cancer makes its way into bone.