Everything in our reality is made up of information. ~ Serbian-born British physicist Vlatko Vedral
Once inured to matter, and to what it took to put matter to work (energy), physicists in the 21st century have increasingly cottoned to the concept that physics is ultimately about information. This arose from trying to reconcile the quantum realm with the cosmological. It is an implicit acknowledgment that reality is fundamentally immaterial.
A century of physics has taught us that information is a crucial player in physical systems and processes. Regard the physical world as made of information, with energy and matter as incidentals. ~ Israeli physicist Jacob Bekenstein
A key issue is how information is encoded to present the 3D spatial world which we perceive. Interfaces at the different scales of existence illustrate the problem.